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How Temperature Can Affect Medication Stability

Joe Dickman | February 11th, 2020

The High Stakes of Medication Storage

Imagine a life-saving medication losing its effectiveness during transportation, leaving patients without the treatment they desperately need. Whether it’s insulin for diabetics, vaccines for preventing disease, or antibiotics for fighting infections, maintaining the stability of these medications is not just important—it’s critical.

Improper temperature control during storage or transportation can render medications useless or even harmful, putting patients at risk and damaging trust in healthcare providers. Understanding how temperature affects medication stability is the first step toward ensuring safe and effective delivery.

How Temperature Affects Medication Stability

Chemical Stability: The Core of Medication Effectiveness

Medications are made up of carefully balanced chemicals designed to interact with the body in specific ways. However, these chemicals are highly sensitive to environmental conditions, particularly temperature:

  • Heat Damage: Prolonged exposure to high temperatures can cause medications to break down, leading to the formation of impurities. These impurities can reduce the medication’s potency and may even create harmful byproducts.
  • Cold Damage: Extreme cold can degrade protein-based medications, such as insulin and vaccines. Once frozen, these products often become unusable and lose their ability to help patients.

Failing to maintain the correct temperature can turn effective treatments into liabilities.

Physical Changes as Warning Signs

Temperature fluctuations can cause noticeable physical changes in medications, often signaling a loss of stability:

  • Color and Texture: Medicines may change color, become grainy, or develop an unusual texture.
  • Odor and Taste: A foul odor or off-putting taste may indicate chemical breakdown.
  • Viscosity: For liquid medications, changes in thickness can suggest chemical alterations, compromising the medication’s effectiveness.

Spotting these changes early can prevent potentially harmful usage.

How to Ensure Medication Stability During Transportation

Maintaining proper conditions during transportation is essential to preserving medication potency. Consider these best practices:

1. Follow WHO Recommendations

The World Health Organization advises:

  • Storing medications in well-ventilated, odor-free, and light-controlled spaces.
  • Maintaining humidity levels below 60%.
  • Ensuring precise temperature control specific to each medication type. For instance, many medications require storage at approximately 5°C (41°F) to remain effective.

2. Invest in Insulated Refrigerated Vehicles

The most reliable solution for transporting temperature-sensitive medications is using insulated trucks equipped with advanced refrigeration technology. These vehicles provide:

  • Precise Temperature Control: Maintains the required conditions throughout transit.
  • Consistent Cooling: Prevents fluctuations that could damage medications.
  • Reliability: Minimizes risks of loss or damage, ensuring patients receive effective treatments.

At Emerald Transportation Solutions, we specialize in vehicles designed to meet these stringent requirements, providing peace of mind for healthcare providers and patients alike.

The Emerald Solution

The stakes for proper medication storage and transportation couldn’t be higher. Extreme temperatures can compromise chemical stability, degrade effectiveness, and put lives at risk. By following best practices and using high-quality refrigerated vehicles, you can ensure that your medications arrive at their destination safe, effective, and ready to save lives.

Emerald Transportation Solutions offers state-of-the-art refrigerated vehicles designed specifically for transporting pharmaceuticals. Contact our team today to find the ideal solution for your business and protect the health of your patients.

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Feel Free To Contact Us If You Have Any Questions

What does under DOT mean?

Questions regarding DOT requirements come up often. 10,000 lbs GVW (gross vehicle weight) and over are commercial vehicles that fall under the Department of Transportation regulatory requirements.

What is the difference between GVW and payload?

GVW or Gross Vehicle Weight is the entire weight of the vehicle including the payload. The payload weight represents the amount of cargo you are hauling.

What is a self-powered unit and a vehicle-powered unit?

A self-powered unit has its own fuel source and will run independent of the truck. This is the heaviest and most expensive option. While vehicle-powered units run off the engine via a compressor mounted on the engine. These are less expensive and lighter in weight but you must run the truck or plug the electric standby into shore power.

What does K-factor mean and why is that important?

K-factor is a term that stands for the overall insulating value of the container (truck body). Quite simply the lower the K-factor the better the truck body will be able to maintain a given temperature and require less energy to do so.

How much lighter is a Poly Van vs a US spec body?

Poly Van bodies are very light. On average we estimate we are 75-150 lbs per foot lighter than a traditional sheet and post foamed in place body. These weight savings translates to less fuel burn and less CO2 emissions, along with added payload, the most important benefit.

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